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Which of the following is NOT a way that a normal cell can become cancerous as explained?A. Constitutively active receptors where only the cytosolic side of the receptor is present - loss of membrane spanning regionB. Autocrine or paracrine stimulation by an excess of growth factorsC. Receptors where the cytosolic domain is missing by mutationD. Abnormal gene amplification that results in overexpression of receptors in the tumor cell E. Activation of tyrosine kinase domains of RTKs by mutation resulting in the TK domain being always onF. Deletions/mutations that render the receptor constitutively active independent of ligands
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