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which observation suggested to sutherland the involvement of a second messenger in epinephrine's effect on liver cells?a) enzymatic activity was proportional to the amount of calcium added to a cell free extractb) receptor studies indicated that epinephrine was a ligand c) glycogen breakdown was observed only when epinephrine was administered to intact cellsd) glycogen breakdown was observed only when epinephrine and glycogen phosphorylase were mixed
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