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What type of release does oral theophylline have?

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6. A 27-year-old African American woman is seen in the emergency room with complaints of urinary frequency, urgency, and dysuria. A urinary analysis demonstrates bacteria and white blood cells, and she is given trimethoprim/sulfamethoxazole. She now returns with sores and blisters around her mouth and on the inside of her mouth. Given her history and findings, what should you include in the differential of her current complaint?(A) Glucose-6-phosphate dehydrogenasedeficiency(B) Steven-Johnson syndrome(C) Red man syndrome(D) Aplastic anemia(E) Disseminated M. avium-intracellulareinfection
Doggedly "Once in a while there was a person roaming doggedly through the fog, mostly single-worded"
ABSORPTION et DISTRIBTION- Absorption intestinale du ROL.- Stockage hépatique sous forme de rétinyl-esters.- Prise en charge par la RBP plasmatique.- Libération dans le plasma du ROL selon besoins.PENETRATION CELLULAIRE- Liaison RBP-protéine membranaire (= Récepteur membranaire des cellules cibles)- Pénétration du ROL dans la cellule cible (prise en charge par la CRBP)- Transformation en RAL puis en AR qui passe dans le noyau.- Liaison de l’AR avec ses récepteurs nucléairesNB : 2 formes d'AR : - ATTR = Acide Tout Trans Rétinoïque - Acide 9-cis rétinoïqueACTION CELLULAIRE- Fixation de l’AR au récepteur par : - Liaison ionique entre le carboxylate (CO-) et NH3+ de l’Arg - Liaison hydrogène entre une N-alanine et une sérine - Interactions de type hydrophobe le long de chaîne carboné- Le complexe AR–Récepteur se lie à des séquences spécifiques de l'ADN (HRE : hormon responsive element), ce qui entraîne une modulation de l'expression de certains gènes (induction ou répression de ces gènes).

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