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What is the biochemical basis for the emergence of methicillin-resistant Staphylococcus aureus (MRSA) infections?The bacteria have a mutation in the transpeptidase enzyme that prevents methicillin inhibition without altering transpeptidase activity.The bacteria express a variant of the beta-lactamase enzyme that is inhibited by methicillin to prevent methicillin from inhibiting transpeptidase.The bacteria have an activated efflux pump that removes methicillin from the cell to prevent it from inhibiting transpeptidase.The bacteria convert methicillin into D-glutamate, which is a substrate for transpeptidase and thereby stimulates cell wall synthesis.
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