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Transkriptio päättyy, kun RNA-polymeraasi tunnistaa DNA:sta sekvenssin (1). Polymeraasientsyymi liittää RNA:han CPSF:n ja CstF:n ja sitten irtoaa DNA:sta. Tämän jälkeen (2) RNA:n 3'-päähän. Prosessissa tarvitaan (3)-proteiineja, jotka liittyvät mRNA:han.
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