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The cholera bacterium Vibrio cholerae produces an enzyme toxin that chemically modifies a G protein involved in regulating salt and water secretion in intestinal cells. Stuck in its active form, the modified G protein stimulates the production of a high concentration of cAMP, which causes the intestinal cells to secrete large amounts of salts into the intestines, with water following by osmosis. An infected person quickly develops profuse diarrhea and if left untreated can soon die from the loss of water and salts. What is the basic effect of the cholera toxin?
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