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Some ribosomes get transported to the rough endoplasmic reticulum. When the new protein is just beginning to be made, these ribosomes have a 20-24 amino-acid segment, called the ER signal sequence, that corresponds to the N-terminus of the premature protein. What grabs the ER signal sequence and shuttles the ribosome to the translocon in the membrane of the rough endoplasmic reticulum?
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