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Red blood cells and platelets become ensnared in the fibrin web to create a clot of fibrin, blood cells, and platelets

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A 30-year-old man comes to the emergency department because of the sudden onset of back pain beginning 2 hours ago. Beginning yesterday, he noticed that his eyes started appearing yellowish and his urine was darker than normal. Two months ago, he returned from a trip to Greece, where he lived before immigrating to the US 10 years ago. Three days ago, he was diagnosed with latent tuberculosis and started on isoniazid. He has worked as a plumber the last 5 years. His temperature is 37.4°C (99.3°F), pulse is 80/min, and blood pressure is 110/70 mm Hg. Examination shows back tenderness and scleral icterus. Laboratory studies show:Hematocrit 29%Leukocyte count 8000/mm3Platelet count 280,000/mm3Serum Bilirubin Total 4 mg/dLDirect 0.7 mg/dLHaptoglobin 15 mg/dL (N=41-165 mg/dL)Lactate dehydrogenase 180 U/LUrine Blood 3+Protein 1+RBC 2-3/hpfWBC 2-3/hpfWhich of the following is the most likely underlying cause of this patient's anemia?

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