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Only 11% of the predictable interactions have clinical importance
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- Drug Name/Class: Class III (K+ channel blockers) ADIDS (Amiodarone, Dofetilide, Ibutilide, Dronaderone, Sotalol) MOA: K+ channel blockade blocks outward current of phase 3 repolarization (the bananas are supposed to represent potassium), prolongs PR and QT, (the sign) prolongs purkinje fiber APClinical Use: SVT (the superman S), A FIB (grass), A Flutter and V Flutter (butterfly), Emergency treatment of ventricular rhythms including V FIB (the shoe laces), V Tach (tacks holding the sign) Adverse Effects: Many interactions (warfarin, digoxin, statins, cyclosporine). Amiodarone: pulmonary fibrosis, hepatotoxicity, corneal deposits, hypo/hyper thyroids, constipation, neuron symptoms, permanent blue/grey skin (the shoe is blue, other effects not shown... just think of amiodarone being kind of the worst of any of these). Sotolol can cause Torsades.
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