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OI pathophysiology:- Deficiency in the synthesis of _____ _____ _____ ("too little bone") - _____ _____ mutations --> Loss of function --> Defective assembly of collagen polypeptides- Primarily affects bone but also impacts joints, eyes, ears, skin, and teeth resulting in blue sclera, hearing loss, thin skin, and dental imperfections - Fundamental abnormality in OI is too little _____, resulting in extreme skeletal _____

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