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Maternal blood analysis: - _____ (pregnancy-associated plasma protein A) and free beta-subunit of human chorionic gonadotropin (_____) --> Estimate risks for _____ 21 and 18 (1st trimester) - _____ screen: maternal alpha-fetoprotein (AFP), hCG, unconjugated estradiol, and inhibin --> Estimate risks for trisomies 21 and 18 (2nd trimester) - _____ sequencing --> Specific chromosome imbalances - _____ tests --> Need to be confirmed by another method

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