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La dégénération fibrillaire est caractérisée par une accumulation anormale de __ qui participe à la polymérisation de la __ et à la stabilisation des __. L'interaction tau/microtubule est régulée par la __ de Tau. A l'état patho, il y a une __ causée par la toxicité de la __ ce qui entraine une __ de l'affinité de Tau pr les microtubules entrainant leur désorganisation et la formation des __
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