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L'épithélium lingual repose sur un chorion assez dense qui se prolonge par des travées conjonctives pénétrant entre les faisceaux musculaires. Dans celui-ci se disséminent des glandes salivaires accessoires. Par endroit, en arrière du V lingual, des cellules lymphoïdes se regroupent pour former les amygdales linguales.Toutefois, le support conjonctif de la langue est assez mince ce qui explique qu'en cas de morsure, la blessure atteint rapidement le muscle sous-jacent. Celui-ci est très vascularisé et particulièrement bien innervé.
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