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In general, strong (charged) nucleophiles favor which reaction?
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- a hydrocarbon chain containing only single bonds
- by an SN2 reaction involving sodium hydrosulfide (HS-) so primary alkyl halides work best
- thiol deprotonated by OH to form thiolate ion, thiolate ion functions as a nucleophile and attacks an alkyl halide (good nucleophile turns into a great nucleophile)