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oxidative stress, mitochondrial dysfunction, loss of nerve growth factor or lewy body formation leads to producing the classic triad of CM
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- abrupt imbalance between excitatory and inhibitory impulses leads to increased Ca2+ (glutamate) and decreased Cl- (gaba)
- classic's triad: bradykinesia or ankesia, tremors (pill rolling rigidity), stooped posture, dysphagia
- most common initial: paresthesia of face, trunk, and limbs; weakness, impaired gait, urinary incontinence, blurred vision, difficulty speaking