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defect in pyruvate oxidationdefect in the mitochondrial electron transport chainDefect in pyruvate oxidation will result in accumulation of pyruvate, which will then be converted to lactic acid via the lactic acid fermentation pathway. A defect in the ETC will prevent regeneration of NAD+ from NADH; high NADH and low NAD+ then cause pyruvate to be fermented to lactic acid.

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